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Cannabinoids are synthesized by Cannabigerolic Acid. CBG is the decarboxylated form of this acid that appears at low levels in most cannabis plants. Because its properties are beneficial to multiple parts of the endocannabinoid system, CBG has a wide range of therapeutic uses. It is non-psychotropic and can provide analgesic and antidepressant qualities.

THCV sets itself apart from its cousin THC with its distinct lack of psychoactive effects. THCV also acts as an allosteric modulator for Delta-9-THC thus reducing its psychoactivity. It has been found to be helpful as an appetite suppressant, neuroprotectant and glycemic control in type 2 diabetics.